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KMID : 0358320080490020168
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Korean Journal of Urology
2008 Volume.49 No. 2 p.168 ~ p.173
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A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis
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Kim Jun-Mo
Kim Young-Sig
Namgoong Mee-Kyung
Park Kwan-Hyun
Park Yong-Hoon
Lee Sang-Don
Lee Seung-Joo
Chung Jae-Yong
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Abstract
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Purpose: We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis(NE).
Materials and Methods: The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups: group 1(imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2(desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data.
Results: Mean wetting events in group 1 decreased from 8.8 to 5.1 times(2 weeks) and 3.0 times(4 weeks)(p=0.009) versus 10.2 to 5.5 times(2 weeks) and 6.4 times(4 weeks)(p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9(baseline), 4.4(2 weeks), and 3.7(4 weeks), and, for group 2, 5.1(baseline), 4.8(2 weeks), and 4.8(4 weeks). The two groups were not different(p=0.14, p=0.73).
Conclusions: Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability. (Korean J Urol 2008;49:168-173)
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KEYWORD
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Nocturnal enuresis, Arousal, Imipramine, Deamino arginine vasopressin
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